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GENE - TERM ANNOTATION REPORT

RGD ID: 12192059
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1B ISOIL1B (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2; protein:decreased tyrosine phosphorylation:vitreous humorPMID:18978347 REF_RGD_ID:2307061
IL1B ISOIL1B (Homo sapiens)9068941RGDprotein:increased expression:serum, vitreous humourPMID:16284605 REF_RGD_ID:7401212
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