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GENE - TERM ANNOTATION REPORT

RGD ID: 12192059
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: DOID:850
Term: lung disease
Definition: A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. (DO)
Definition Source(s): http://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000066.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1B ISOIl1b (Mus musculus)9068941RGDassociated with Hyperoxia;mRNA, protein:increased expression:lungPMID:9641262 REF_RGD_ID:4143189
IL1B ISOIl1b (Mus musculus)9068941RGDassociated with Reperfusion Injury;protein:increased expression:lungPMID:19941004 REF_RGD_ID:4142814
IL1B ISOIl1b (Rattus norvegicus)9068941RGDassociated with Endotoxemia;protein:increased expression:lungPMID:19843795 REF_RGD_ID:4142819
IL1B ISOIl1b (Rattus norvegicus)9068941RGDassociated with Pancreatitis;protein:increased expression:serumPMID:19926967 REF_RGD_ID:4142815
IL1B ISOIl1b (Rattus norvegicus)9068941RGDassociated with Shock, HemorrhagicPMID:20041965 REF_RGD_ID:4142810
IL1BsusceptibilityISOIL1B (Homo sapiens)9068941RGDassociated with Scleroderma, Systemic;DNA:SNP: :3962C>T (human)PMID:17584583 REF_RGD_ID:4142870
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