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GENE - TERM ANNOTATION REPORT

RGD ID: 12156793
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: RNGTT
Name: RNA guanylyltransferase and 5'-phosphatase
Acc ID: GO:0006370
Term: 7-methylguanosine mRNA capping
Definition: The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.
Definition Source(s): GOC:mah, PMID:9266685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RNGTTinvolved_inIEAUniProtKB:O60942 or ensembl:ENSP00000358497150520179Ensembl GO_REF:0000107
RNGTTinvolved_inIEAInterPro:IPR001339 or InterPro:IPR017074150520179InterPro GO_REF:0000002
RNGTTinvolved_inIEAPANTHER:PTHR10367:SF17150520179TreeGrafter GO_REF:0000118
RNGTTinvolved_inIEAUniProtKB-KW:KW-0506150520179UniProt GO_REF:0000043
RNGTTinvolved_inIEAUniRule:UR000357751150520179UniProt GO_REF:0000104
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