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RGD ID: 12123348
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: FBXL7
Name: F-box and leucine rich repeat protein 7
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FBXL7 IBAFB:FBgn0038385, MGI:MGI:3052506, PANTHER:PTN002547163, SGD:S000004344, TAIR:locus:2027082, TAIR:locus:2102400, TAIR:locus:2145512, TAIR:locus:2149805, UniProtKB:Q5VMP0, UniProtKB:Q9H469, UniProtKB:Q9UJT9, UniProtKB:Q9UKA1, UniProtKB:Q9UKC9, ZFIN:ZDB-GENE-030131-3556, ZFIN:ZDB-GENE-030131-592013508589GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.