Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	12106823
Species:	Canis lupus familiaris
RGD Object:	Gene
Symbol:	NEDD4
Name:	NEDD4 E3 ubiquitin protein ligase

Acc ID:	GO:0061630
Term:	ubiquitin protein ligase activity
Definition:	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Definition Source(s):	GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
NEDD4	enables	IEA	UniProtKB:P46934 or ensembl:ENSP00000410613	150520179	Ensembl		GO_REF:0000107
NEDD4	enables	IEA	InterPro:IPR024928	150520179	InterPro		GO_REF:0000002
NEDD4	enables	IEA	PANTHER:PTHR11254:SF282	150520179	TreeGrafter		GO_REF:0000118

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