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GENE - TERM ANNOTATION REPORT

RGD ID: 12079702
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: DOID:1470
Term: major depressive disorder
Definition: A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Major_depressive_disorder "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/30333763 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6 ISOIL6 (Homo sapiens)9068941RGDassociated with Hepatitis C, Chronic;DNA:SNP, haplotype:promoter:-174G>C (human)PMID:30734130 REF_RGD_ID:14975122
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