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GENE - TERM ANNOTATION REPORT

RGD ID: 12076681
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: DOID:850
Term: lung disease
Definition: A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. (DO)
Definition Source(s): http://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000066.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1 ISOSERPINE1 (Homo sapiens)9068941RGDAcute Lung Injury; protein:increased expression:plasmaPMID:19855955 REF_RGD_ID:4143514
SERPINE1 ISOSERPINE1 (Homo sapiens)9068941RGDVentilator-Induced Lung Injury; mRNA, protein:increased expression, increased activity:Bronchoalveolar Lavage Fluid, plasmaPMID:20110652 REF_RGD_ID:4143512
SERPINE1severityISOSERPINE1 (Homo sapiens)9068941RGDacute lung injury; associated with Pulmonary Edema; protein:increased expression:lung, plasmaPMID:12730079 REF_RGD_ID:4144040
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