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GENE - TERM ANNOTATION REPORT

RGD ID: 12070277
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: PRDM1
Name: PR/SET domain 1
Acc ID: DOID:7148
Term: rheumatoid arthritis
Definition: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Definition Source(s): MESH:D001172, http://en.wikipedia.org/wiki/Rheumatoid_arthritis, http://www.arthritis.org/disease-center.php?disease_id=31, http://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/home/ovc-20197388, http://www.medicinenet.com/rheumatoid_arthritis/article.htm, http://www.nlm.nih.gov/medlineplus/ency/article/000431.htm, http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=rheumatoid%20arthritis
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSRGD:13233919068941CTDCTD Direct Evidence: marker/mechanism

PMID:19898481, PMID:20453842, PMID:23143596
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.