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GENE - TERM ANNOTATION REPORT

RGD ID: 12060047
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: HMGB1
Name: high mobility group box 1
Acc ID: DOID:9002211
Term: Hyperalgesia
Definition: An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Definition Source(s): MESH:D006930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGB1treatmentISOHmgb1 (Rattus norvegicus)9068941RGD PMID:24077211 PMID:30142543 REF_RGD_ID:13838658 REF_RGD_ID:7364865
HMGB1 ISOHMGB1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:27474498
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