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GENE - TERM ANNOTATION REPORT

RGD ID: 12055108
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: GABRA1
Name: gamma-aminobutyric acid type A receptor subunit alpha1
Acc ID: GO:0051932
Term: synaptic transmission, GABAergic
Definition: The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:dos, ISBN:0126603030
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GABRA1involved_inIEAUniProtKB:P14867 or ensembl:ENSP00000377517150520179Ensembl GO_REF:0000107
GABRA1involved_inIBAPANTHER:PTN000436343 or Gabra1 (Rattus norvegicus) or Gabra6 (Rattus norvegicus) or Gabrg2 (Rattus norvegicus) or UniProtKB:P14867 or UniProtKB:P18507150520179GO_Central GO_REF:0000033
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