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GENE - TERM ANNOTATION REPORT

RGD ID: 12022381
Species: Pan paniscus
RGD Object: Gene
Symbol: PIAS1
Name: protein inhibitor of activated STAT 1
Acc ID: PW:0000209
Term: Jak-Stat signaling pathway
Definition: The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand- triggered signaling through the various receptors.
Definition Source(s): GO:0007259, KEGG:map04630, MCW library:Handbook of cellular and molecular immunology, PMID:12039028, PMID:14668806, PMID:14737178, PMID:17312100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PIAS1 ISOPIAS1 (Homo sapiens)9068941RGD PMID:14607831 PMID:16426581 REF_RGD_ID:1357941 REF_RGD_ID:2290530
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