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GENE - TERM ANNOTATION REPORT

RGD ID: 11997637
Species: Pan paniscus
RGD Object: Gene
Symbol: AKR1B1
Name: aldo-keto reductase family 1 member B
Acc ID: DOID:9743
Term: diabetic neuropathy
Definition: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Definition Source(s): MESH:D003929
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1B1 ISOAkr1b1 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:16900242 REF_RGD_ID:1626089
AKR1B1susceptibilityISOAKR1B1 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 1;DNA:repeat:promoter:g.(CA)n (human)PMID:9489533 REF_RGD_ID:8548642
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