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GENE - TERM ANNOTATION REPORT

RGD ID: 11969517
Species: Pan paniscus
RGD Object: Gene
Symbol: ITGB3
Name: integrin subunit beta 3
Acc ID: DOID:9003340
Term: Neonatal Alloimmune Thrombocytopenia
Definition: A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.
Definition Source(s): MESH:D054098
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ITGB3 ISOITGB3 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Ca/Tu ALLOANTIGEN POLYMORPHISM | ClinVar Annotator: match by term: Fetal and neonatal alloimmune thrombocytopenia | ClinVar Annotator: match by term: Mo ALLOANTIGEN POLYMORPHISM | ClinVar Annotator: match by term: PEN(a)/PEN(b) ALLOANTIGEN POLYMORPHISMPMID:1430225 PMID:14516468 PMID:21658138 PMID:2257303 PMID:25741868 PMID:25827233 PMID:28370162 PMID:28492532 PMID:7694683 PMID:8093349 PMID:8457479 PMID:9787162
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