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GENE - TERM ANNOTATION REPORT

RGD ID: 11959478
Species: Pan paniscus
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: DOID:9006646
Term: Metabolic Syndrome
Definition: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3treatmentISONos3 (Rattus norvegicus)9068941RGD PMID:28967023 REF_RGD_ID:13461762
NOS3 ISONOS3 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Metabolic syndrome, susceptibility toPMID:28361419
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