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GENE - TERM ANNOTATION REPORT

RGD ID: 11959478
Species: Pan paniscus
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: DOID:0050848
Term: obstructive sleep apnea
Definition: A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Obstructive_sleep_apnea "DO" "DO", http://www.mayoclinic.org/diseases-conditions/sleep-apnea/basics/definition/con-20020286 "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000811.htm "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK63555/#executivesummary.s1 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3 ISONOS3 (Homo sapiens)9068941RGDassociated with heart failure; protein:decreased expression:serumPMID:16806535 REF_RGD_ID:4892059
NOS3 ISONOS3 (Homo sapiens)9068941RGDDNA:polymorphism:exon: p. E298D (human)PMID:18651156 REF_RGD_ID:4892052
NOS3 ISONOS3 (Homo sapiens)9068941RGDprotein:decreased expression, decreased phosphorylation:endothelial cellsPMID:20159829 REF_RGD_ID:4892051
NOS3severityISONOS3 (Homo sapiens)9068941RGDprotein:increased expression:endothelial cellPMID:18413499 REF_RGD_ID:4891909
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