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GENE - TERM ANNOTATION REPORT

RGD ID: 11929106
Species: Pan paniscus
RGD Object: Gene
Symbol: LEP
Name: leptin
Acc ID: DOID:9970
Term: obesity
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Obesity "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LEPno_associationISOLEP (Homo sapiens)9068941RGDin a US Caucasian populationPMID:15910756 REF_RGD_ID:1643130
LEPtreatmentISOLep (Rattus norvegicus)9068941RGD PMID:23793169 REF_RGD_ID:10053638
LEPtreatmentISOLep (Mus musculus)9068941RGDmouse protein in a rat modelPMID:10029567 REF_RGD_ID:10053612
LEP ISOLEP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Monogenic Non-Syndromic ObesityPMID:25741868 PMID:28492532
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