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GENE - TERM ANNOTATION REPORT

RGD ID: 11899196
Species: Pan paniscus
RGD Object: Gene
Symbol: DRD2
Name: dopamine receptor D2
Acc ID: DOID:9008394
Term: Drug-Induced Dyskinesia
Definition: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Definition Source(s): MESH:D004409
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DRD2 ISODrd2 (Rattus norvegicus)9068941RGD PMID:18707801 REF_RGD_ID:2311579
DRD2 ISODRD2 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:10534246 PMID:14629710 PMID:7845605
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