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GENE - TERM ANNOTATION REPORT

RGD ID: 11856432
Species: Pan paniscus
RGD Object: Gene
Symbol: UBA52
Name: ubiquitin A-52 residue ribosomal protein fusion product 1
Acc ID: GO:0042276
Term: error-prone translesion synthesis
Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.
Definition Source(s): GOC:elh, GOC:jl, PMID:11485998
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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