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GENE - TERM ANNOTATION REPORT

RGD ID: 11827580
Species: Pan paniscus
RGD Object: Gene
Symbol: GPX4
Name: glutathione peroxidase 4
Acc ID: GO:0047066
Term: phospholipid-hydroperoxide glutathione peroxidase activity
Definition: Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.
Definition Source(s): EC:1.11.1.12, MetaCyc:1.11.1.12-RXN
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSRGD:7360499068941GO_Central PMID:21873635
 ISSRGD:7360499068941Reactome Reactome:R-HSA-9018868, Reactome:R-HSA-9018895, Reactome:R-HSA-9020271, Reactome:R-HSA-9020273
 ISSRGD:7360499068941UniProtKB GO_REF:0000024
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.