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GENE - TERM ANNOTATION REPORT

RGD ID: 11824331
Species: Pan paniscus
RGD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTNNB1involved_inIEAUniProtKB:P35222 or UniProtKB:Q02248 or ensembl:ENSMUSP00000007130 or ensembl:ENSP00000344456150520179Ensembl GO_REF:0000107
CTNNB1acts_upstream_of_or_withinISOMGI:1093309068941MGI PMID:16678101

PMID:16678101
CTNNB1acts_upstream_of_or_withinISOMGI:1261834 or MGI:989549068941MGI PMID:19686689

PMID:19686689
CTNNB1acts_upstream_of_or_withinISOMGI:2148567 and MGI:35771069068941MGI PMID:19690384

PMID:19690384
CTNNB1acts_upstream_of_or_withinISOMGI:24460849068941MGI PMID:16818445

PMID:16818445
CTNNB1acts_upstream_of_or_withinISOMGI:989579068941MGI PMID:20454446

PMID:20454446
CTNNB1acts_upstream_of_or_withinISOCtnnb1 (Mus musculus)9068941MGI PMID:12235125 PMID:12464179 PMID:12717450 PMID:15781477 PMID:31222549

PMID:12235125 PMID:12464179 PMID:12717450 PMID:15781477 PMID:31222549
CTNNB1acts_upstream_of_or_withinISOCtnnb1 (Mus musculus)9068941MGI PMID:19060336 PMID:19619491

PMID:19060336 PMID:19619491
CTNNB1involved_inIEAPANTHER:PTHR45976:SF4150520179TreeGrafter GO_REF:0000118
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