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GENE - TERM ANNOTATION REPORT

RGD ID: 11770874
Species: Pan paniscus
RGD Object: Gene
Symbol: BTK
Name: Bruton tyrosine kinase
Acc ID: DOID:9002227
Term: B-Cell Chronic Lymphocytic Leukemia
Definition: A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
Definition Source(s): MESH:D015451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BTKtreatmentISOBTK (Homo sapiens)9068941RGD PMID:23045577 REF_RGD_ID:11040699
BTK ISOBTK (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: B-cell chronic lymphocytic leukemiaPMID:24869598 PMID:25741868 PMID:28492532
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