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GENE - TERM ANNOTATION REPORT

RGD ID: 11732391
Species: Pan paniscus
RGD Object: Gene
Symbol: AGER
Name: advanced glycosylation end-product specific receptor
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGER ISOAger (Rattus norvegicus)9068941RGDprotein:increased expression:retina inner nuclear layer, retinal ganglion cell (rat)PMID:23587252 REF_RGD_ID:7244248
AGER ISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:SNP: :2245G>A (human)PMID:22116960 REF_RGD_ID:8695967
AGER ISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A (human)PMID:16969646 REF_RGD_ID:8695958
AGER ISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-429T>C (human)PMID:11375354 REF_RGD_ID:8695966
AGER ISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;protein:increased expression:serumPMID:23091285 REF_RGD_ID:7244174
AGERno_associationISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:polymorphisms: :p.G82S, 1704G>T, 2184A>G (human)PMID:22427038 REF_RGD_ID:8695983
AGERno_associationISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:polymorphisms:promoter, cds, intron:g.-443T>C, p.G82S, g.1704G>T (rs1800625, rs2070600, rs184003) (human)PMID:22475522 REF_RGD_ID:7244176
AGERno_associationISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A, - 429T>C (human)PMID:14704946 REF_RGD_ID:8695965
AGERseverityISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 1;DNA:SNP:promoter:-374T>A (human)PMID:16969646 REF_RGD_ID:8695958
AGERsusceptibilityISOAGER (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:missense mutation, snp, haplotype:cds, intron:p.G82S, g.1704G>T (human)PMID:19542745 REF_RGD_ID:7244175
AGERtreatmentISOAger (Rattus norvegicus)9068941RGD PMID:23146804 REF_RGD_ID:7244369
AGERtreatmentISOAger (Mus musculus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:22171162 REF_RGD_ID:8695979
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