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GENE - TERM ANNOTATION REPORT

RGD ID: 11729366
Species: Pan paniscus
RGD Object: Gene
Symbol: MME
Name: membrane metalloendopeptidase
Acc ID: PW:0000529
Term: angiotensin (1-7) signaling pathway
Definition: Angiotensin (1-7) is derived from angiotensin II through the action of angiotensin converting enzyme 2 (ACE2) or from angiotensin I through the action of neutral endopeptidase (NEP). Angiotensin (1-7) signaling appears to have a vasodilatory effect but the exact action of this peptide in humans remains to be established.
Definition Source(s): PMID:15687842, PMID:15962175, PMID:16520407
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MME ISOMme (Rattus norvegicus)9068941RGD PMID:10642323 REF_RGD_ID:1581953
MME ISOMME (Homo sapiens)9068941RGD PMID:15638741 PMID:16520407 REF_RGD_ID:1581742 REF_RGD_ID:1581931
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