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GENE - TERM ANNOTATION REPORT

RGD ID: 11705261
Species: Pan paniscus
RGD Object: Gene
Symbol: AKR1A1
Name: aldo-keto reductase family 1 member A1
Acc ID: PW:0001565
Term: doxorubicin pharmacokinetics pathway
Definition: The pathway of processing - absorption, distribution, metabolism or elimination - of doxorubicin. Doxorubicin is used as a chemotherapeutic agent for the treatment of various cancers. Its use is limited by the serious cardiotoxic side effects it exerts. Genetic variations can result in changes in the availability of the drug.
Definition Source(s): PMID:21048526
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1A1 ISORGD:684869068941SMPDB SMP:00650
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.