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GENE - TERM ANNOTATION REPORT

RGD ID: 11681032
Species: Pan paniscus
RGD Object: Gene
Symbol: SHH
Name: sonic hedgehog signaling molecule
Acc ID: GO:0030324
Term: lung development
Definition: The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
Definition Source(s): GOC:jid, UBERON:0002048
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHHinvolved_inIEAUniProtKB:Q62226 or ensembl:ENSMUSP00000002708150520179Ensembl GO_REF:0000107
SHHacts_upstream_of_or_withinISOMGI:18577969068941MGI PMID:15136151 PMID:17187775 PMID:9731532

PMID:15136151 PMID:17187775 PMID:9731532
SHHacts_upstream_of_or_withinISOMGI:19342619068941MGI PMID:9768363

PMID:9768363
SHHacts_upstream_of_or_withinISOMGI:1934268 or MGI:26795249068941MGI PMID:15305287

PMID:15305287
SHHacts_upstream_of_or_withinISOMGI:957299068941MGI PMID:15136151

PMID:15136151
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