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GENE - TERM ANNOTATION REPORT

RGD ID: 11680809
Species: Pan paniscus
RGD Object: Gene
Symbol: LOC100989105
Name: signal transducer and activator of transcription 5B
Acc ID: PW:0000209
Term: Jak-Stat signaling pathway
Definition: The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand- triggered signaling through the various receptors.
Definition Source(s): GO:0007259, KEGG:map04630, MCW library:Handbook of cellular and molecular immunology, PMID:12039028, PMID:14668806, PMID:14737178, PMID:17312100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LOC100989105 ISOStat5b (Mus musculus)9068941RGD PMID:17312100 REF_RGD_ID:1625126
LOC100989105 ISOStat5b (Rattus norvegicus)9068941RGD PMID:11064147 PMID:12193540 REF_RGD_ID:1624963 REF_RGD_ID:628356
LOC100989105 ISOSTAT5B (Homo sapiens)9068941RGD PMID:17312100 REF_RGD_ID:1625126
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