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GENE - TERM ANNOTATION REPORT

RGD ID: 11670181
Species: Pan paniscus
RGD Object: Gene
Symbol: SNCA
Name: synuclein alpha
Acc ID: PW:0000018
Term: Parkinson's disease pathway
Definition: One of the most common neurodegenerative diseases that is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy bodies in surrounding neurons. Several pathways are thought to be deregulated; for instance, imbalance of iron homeostasis is believed to contribute to the pathogenesis of the condition.
Definition Source(s): KEGG:map05012, PMID:18052765, PMID:19422283
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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