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GENE - TERM ANNOTATION REPORT

RGD ID: 11491
Species: Mus musculus
RGD Object: Gene
Symbol: Wnt1
Name: wingless-type MMTV integration site family, member 1
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt1involved_inIDA 2290270BHF-UCL MGI:4835152 PMID:15265686 MGI:5009183 PMID:12121999 MGI:5693230 PMID:17239604 MGI:5705221 PMID:19951692

MGI:4835152 MGI:5009183 MGI:5693230 MGI:5705221 PMID:12121999 PMID:15265686 PMID:17239604 PMID:19951692
Wnt1involved_inIBAPANTHER:PTN000246517 or FB:FBgn0004360 or UniProtKB:Q98SN7 or Wnt7a (Rattus norvegicus) or UniProtKB:O00744 or FB:FBgn0284084 or MGI:98962 or UniProtKB:P56705 or WB:WBGene00003395 or MGI:98954 or FB:FBgn0031902 or UniProtKB:O14904 or UniProtKB:P56703 or MGI:98956 or UniProtKB:P56706 or UniProtKB:Q93098 or MGI:98955 or UniProtKB:Q9GZT5 or ZFIN:ZDB-GENE-990415-279 or UniProtKB:Q9H1J5 or MGI:1261834 or MGI:98953 or MGI:98957 or MGI:101948 or MGI:2446084 or MGI:1197020 or WB:WBGene00001188 or UniProtKB:P09544 or UniProtKB:P04628 or ZFIN:ZDB-GENE-980526-332 or UniProtKB:P56704 or UniProtKB:O14905 or MGI:108061 or MGI:98961 or UniProtKB:Q93097 or MGI:98958 or UniProtKB:O007552290270GO_Central GO_REF:0000033
Wnt1acts_upstream_of_or_withinIDA 2290270MGI PMID:10937998 PMID:11265645 PMID:15064719 PMID:15282335 PMID:16207730 PMID:16543246 PMID:20383322 PMID:9652750

PMID:10937998 PMID:11265645 PMID:15064719 PMID:15282335 PMID:16207730 PMID:16543246 PMID:20383322 PMID:9652750
Wnt1acts_upstream_of_or_withinIGIMGI:13290402290270MGI PMID:15143170

PMID:15143170
Wnt1involved_inISOUniProtKB:P046282290270MGI GO_REF:0000119 MGI:4834177
Wnt1involved_inNAS 2290270ParkinsonsUK-UCL MGI:3045659 PMID:15121182

MGI:3045659 PMID:15121182
Wnt1involved_inTAS 2290270ParkinsonsUK-UCL MGI:5693988 PMID:26049140

MGI:5693988 PMID:26049140
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