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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11481
Species: Mus musculus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VCAM1 mRNA; Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of VCAM1 mRNA]PMID:12072388 PMID:17942748
Vcam1decreases expressionISOVcam1 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of VCAM1 mRNA; Ethinyl Estradiol results in decreased expression of VCAM1 proteinPMID:16223672 PMID:16735947 PMID:17351261 PMID:17557909
Vcam1multiple interactionsISOVcam1 (Rattus norvegicus)6480464CTDEthinyl Estradiol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of VCAM1 protein]PMID:16223672 PMID:16735947
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein; [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of VCAM1 protein; [Ethinyl Estradiol co-treated with norethindrone acetate] results in decreased expression of VCAM1 protein; Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of VCAM1 protein]PMID:15769986 PMID:17105841 PMID:17903073
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