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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11481
Species: Mus musculus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of VCAM1 mRNA; Oxygen deficiency results in increased expression of VCAM1 proteinPMID:24205000 PMID:25448280 PMID:30096613
Vcam1multiple interactionsEXP 6480464CTD[NFE2L2 protein affects the susceptibility to sulforaphane] affects the reaction [Oxygen deficiency results in increased expression of VCAM1 protein]; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of VCAM1 protein; NFE2L2 protein affects the reaction [Oxygen deficiency results in increased expression of VCAM1 protein]; sulforaphane inhibits the reaction [Oxygen deficiency results in increased expression of VCAM1 protein]PMID:29651748 PMID:30096613
Vcam1increases expressionISOVcam1 (Rattus norvegicus)6480464CTDOxygen deficiency results in increased expression of VCAM1 proteinPMID:18635243 PMID:21296072
Vcam1multiple interactionsISOVcam1 (Rattus norvegicus)6480464CTDcobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of VCAM1 protein]PMID:18635243 PMID:21296072
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTD[N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride co-treated with PLAT protein] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of VCAM1 protein]; [Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of VCAM1 protein; tanshinone II A sodium sulfonate inhibits the reaction [[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of VCAM1 protein]PMID:28294475 PMID:29651748
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