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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of UGT1A1 mRNAPMID:19144771
Ugt1a1increases expressionEXP 6480464CTDDexamethasone results in increased expression of UGT1A1 mRNAPMID:21041162 PMID:29222744
Ugt1a1multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA; Dexamethasone promotes the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]; Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]PMID:16155002 PMID:29222744
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of UGT1A1 mRNA; Dexamethasone results in increased expression of UGT1A1 proteinPMID:15557560 PMID:15560369
Ugt1a1increases expressionISOUgt1a1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of UGT1A1 mRNAPMID:15102944 PMID:20607812
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