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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:35591
Term: pregnenolone 16alpha-carbonitrile
Definition: An aliphatic nitrile that has formula C22H31NO2.
Chemical ID: MESH:D011285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDPregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA, Pregnenolone Carbonitrile results in increased expression of UGT1A7 mRNA

PMID:19144771, PMID:22496397
multiple interactionsEXP 6480464CTD[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A1 mRNA, Dexamethasone promotes the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA], NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA]

PMID:16155002, PMID:22496397
increases activityISORGD:13500186480464CTDPregnenolone Carbonitrile results in increased activity of UGT1A1 protein

PMID:16155002, PMID:27413119
increases expressionISORGD:13500186480464CTDPregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA, Pregnenolone Carbonitrile results in increased expression of UGT1A1 protein

PMID:16155002, PMID:27413119
increases expressionISORGD:39356480464CTDPregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA

PMID:19162173, PMID:22659317
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.