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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13500186480464CTDMethylcholanthrene results in increased expression of UGT1A1 mRNA

PMID:19118567
increases expressionISORGD:39356480464CTDMethylcholanthrene results in increased expression of UGT1A1 mRNA, Methylcholanthrene results in increased expression of UGT1A1 protein

PMID:1435739, PMID:18203689
multiple interactionsISORGD:39356480464CTD[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 3, 6-dihydroxychrysene, [Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 6-hydroxychrysene

PMID:1435739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.