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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of UGT1A1 mRNA

PMID:26377647
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA, Tetrachlorodibenzodioxin results in increased expression of UGT1A1 protein

PMID:19144771, PMID:19474220, PMID:20194756, PMID:21041162, PMID:22213127, PMID:22496397, PMID:24713691, PMID:28213091
multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of UGT1A1 mRNA], [Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of UGT1A1 mRNA, AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA], Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]

PMID:16155002, PMID:22496397, PMID:23756648
decreases expressionISORGD:39356480464CTDTetrachlorodibenzodioxin results in decreased expression of UGT1A1 mRNA

PMID:16054898, PMID:20959002, PMID:21724226, PMID:24355419
increases activityISORGD:13500186480464CTDTetrachlorodibenzodioxin results in increased activity of UGT1A1 protein

PMID:16155002, PMID:16399344
increases expressionISORGD:13500186480464CTDTetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA, Tetrachlorodibenzodioxin results in increased expression of UGT1A1 protein

PMID:16155002, PMID:16399344, PMID:23669205, PMID:29584932
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of Tetrachlorodibenzodioxin metabolite

PMID:15258113
multiple interactionsISORGD:13500186480464CTD[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of UGT1A1 mRNA, AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA], AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to UGT1A1 enhancer] which results in increased expression of UGT1A1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to UGT1A1 promoter], Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to UGT1A1 promoter], Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of UGT1A1 protein

PMID:12566446, PMID:16399344, PMID:17256720, PMID:29162470, PMID:29584932
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.