GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA; [andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] | PMID:35724838 | Tnf | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | andrographolide inhibits the reaction [Copper Sulfate results in increased expression of TNF protein]; andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] | PMID:20946909 PMID:32061742 | | ||||||||||||||||||||||
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