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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDBortezomib inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Bortezomib inhibits the reaction [TNF protein results in increased activity of UPP1 protein]; Bortezomib inhibits the reaction [TNF protein results in increased expression of UPP1 mRNA]PMID:16397116 PMID:28134560
Tnfincreases expressionISOTnf (Rattus norvegicus)6480464CTDBortezomib results in increased expression of TNF mRNAPMID:35121005
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Bortezomib] results in increased expression of TNF protein; [Bortezomib co-treated with TNFSF10 protein] inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Bortezomib inhibits the reaction [TNF protein affects the localization of RELA protein]; Bortezomib promotes the reaction [Fenretinide inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Bortezomib promotes the reaction [Fenretinide inhibits the reaction [TNF protein results in increased activity of RELA protein]]PMID:16230421 PMID:19261616 PMID:20471514 PMID:34861246
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDBerberine inhibits the reaction [Bortezomib results in increased expression of TNF mRNA]PMID:35121005
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