Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:50594
Term: carbon nanotube
Definition: A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.
Chemical ID: MESH:D037742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionEXP 6480464CTDNanotubes, Carbon affects the expression of TNF mRNAPMID:23845593
Tnfaffects secretionEXP 6480464CTDNanotubes, Carbon affects the secretion of TNF proteinPMID:31265265
Tnfdecreases methylationEXP 6480464CTDNanotubes, Carbon results in decreased methylation of TNF promoterPMID:31265265
Tnfincreases expressionEXP 6480464CTDNanotubes, Carbon analog results in increased expression of TNF mRNA; Nanotubes, Carbon results in increased expression of TNF; Nanotubes, Carbon results in increased expression of TNF mRNA; Nanotubes, Carbon results in increased expression of TNF proteinPMID:19428951 PMID:22293422 PMID:25216247 PMID:25510677 PMID:25554681 PMID:25807359 PMID:26048651 PMID:30081225 PMID:32068018
Tnfincreases secretionEXP 6480464CTDNanotubes, Carbon results in increased secretion of TNF mRNA; Nanotubes, Carbon results in increased secretion of TNF proteinPMID:22081859 PMID:25216247
Tnfmultiple interactionsEXP 6480464CTD[Aluminum Oxide co-treated with Nanotubes, Carbon] results in increased expression of TNF mRNA; [Dibutyl Phthalate co-treated with Nanotubes, Carbon] results in increased expression of TNF protein; [Ovalbumin co-treated with Nanotubes, Carbon] results in increased expression of TNF protein; [STAT1 protein affects the susceptibility to Nanotubes, Carbon] affects the reaction [Ovalbumin results in increased expression of TNF protein]; [Vancomycin co-treated with Neomycin co-treated with Cilastatin, Imipenem Drug Combination] inhibits the reaction [Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of TNF protein]]; IL1B protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of TNF protein]; Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of TNF protein]; STAT1 protein affects the reaction [[Ovalbumin co-treated with Nanotubes, Carbon] results in increased expression of TNF protein]; TNF protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of CXCL9 mRNA]; TNF protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of IL1B protein]; TNF protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of NOS2 mRNA]PMID:25216247 PMID:25807359 PMID:32068018 PMID:38285958
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDNanotubes, Carbon results in increased expression of TNF mRNA; Nanotubes, Carbon results in increased expression of TNF proteinPMID:22076105 PMID:27475286
Tnfincreases expressionISOTnf (Rattus norvegicus)6480464CTDNanotubes, Carbon analog results in increased expression of TNF protein; Nanotubes, Carbon results in increased expression of TNF mRNAPMID:19836432 PMID:30605223 PMID:32856799
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDNanotubes, Carbon results in increased secretion of TNF proteinPMID:25216247
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; Aluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of TNF protein]; Lipopolysaccharides promotes the reaction [Nanotubes, Carbon results in increased expression of TNF protein]; Nanotubes, Carbon promotes the reaction [[K-12 lipopolysaccharide binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein]; Nanotubes, Carbon promotes the reaction [[lipopolysaccharide, E coli O55-B5 binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein]; Nanotubes, Carbon promotes the reaction [TLR2 protein results in increased secretion of TNF protein]; Nanotubes, Carbon promotes the reaction [TLR5 protein results in increased secretion of TNF protein]; TNF protein inhibits the reaction [Nanotubes, Carbon analog results in decreased secretion of CXCL8 protein]; TNF protein inhibits the reaction [Nanotubes, Carbon analog results in decreased secretion of IL6 protein]PMID:19041333 PMID:23266719 PMID:25216247 PMID:27475286
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[Nanotubes, Carbon co-treated with Dibutyl Phthalate] results in increased expression of TNF mRNA; [Nanotubes, Carbon co-treated with Dibutyl Phthalate] results in increased expression of TNF protein; kolaviron inhibits the reaction [Nanotubes, Carbon analog results in increased expression of TNF protein]PMID:32856799 PMID:37967788
Go Back to source page   Continue to Ontology report