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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of TNF mRNA; Dinitrochlorobenzene results in increased expression of TNF proteinPMID:16675337 PMID:19647056 PMID:23200891 PMID:23454147 PMID:28826779 PMID:34651546
Tnfincreases secretionEXP 6480464CTDDinitrochlorobenzene results in increased secretion of TNF proteinPMID:22245253
Tnfmultiple interactionsEXP 6480464CTD[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA; [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA; Biological Products inhibits the reaction [Dinitrochlorobenzene results in increased expression of TNF mRNA]; Dinitrochlorobenzene inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Lipopolysaccharides promotes the reaction [Dinitrochlorobenzene results in increased expression of TNF mRNA]; oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA]; Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of TNF mRNA]; sulforaphane inhibits the reaction [Dinitrochlorobenzene results in increased expression of TNF mRNA]; sulforaphane inhibits the reaction [Dinitrochlorobenzene results in increased expression of TNF protein]PMID:12202904 PMID:16687389 PMID:21782934 PMID:23200891 PMID:23454147 PMID:23499868 PMID:34651546
Tnfaffects expressionISOTNF (Homo sapiens)6480464CTDDinitrochlorobenzene affects the expression of TNF mRNAPMID:20385217
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased secretion of TNF proteinPMID:17118622 PMID:18495191 PMID:20417223
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Tetradecanoylphorbol Acetate co-treated with Dinitrochlorobenzene] results in increased expression of and results in increased secretion of TNF protein; Dinitrochlorobenzene inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Dinitrochlorobenzene inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; TNF protein affects the reaction [Dinitrochlorobenzene results in increased expression of CCR7 mRNA]PMID:15304089 PMID:24964617 PMID:7476933
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