GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | decreases expression | EXP | | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of TNF mRNA | PMID:29718165 | Tnf | increases expression | EXP | | 6480464 | CTD | Diethylhexyl Phthalate results in increased expression of TNF mRNA; Diethylhexyl Phthalate results in increased expression of TNF protein | PMID:35196152 PMID:36209858 PMID:36583613 PMID:36774801 PMID:37858774 | Tnf | multiple interactions | EXP | | 6480464 | CTD | 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein]; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of TNF mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of TNF protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of TNF protein; [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of TNF mRNA; [Diethylhexyl Phthalate co-treated with OVAL protein] results in increased expression of TNF mRNA; Diethylhexyl Phthalate affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein] | PMID:23148021 PMID:29718165 PMID:30722647 PMID:35196152 PMID:35739755 PMID:36583613 PMID:36774801 PMID:37364641 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Diethylhexyl Phthalate results in increased expression of TNF mRNA; Diethylhexyl Phthalate results in increased expression of TNF protein | PMID:20082445 PMID:32991955 PMID:36774801 | Tnf | increases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Diethylhexyl Phthalate results in increased expression of TNF protein | PMID:27511800 PMID:37061009 | Tnf | increases secretion | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Diethylhexyl Phthalate results in increased secretion of TNF protein | PMID:35460826 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein]; Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF mRNA]; prolinedithiocarbamate inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF mRNA]; prolinedithiocarbamate inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein]; SLC39A5 protein promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein]]; TNF protein affects the reaction [Diethylhexyl Phthalate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B protein]] | PMID:20082445 PMID:28673093 PMID:32991955 PMID:36774801 | Tnf | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of TNF protein]; [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of TNF mRNA; Verapamil inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of TNF protein] | PMID:33166671 PMID:35460826 | | ||||||||||||||||||||||
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