GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | affects secretion | EXP | | 6480464 | CTD | Aspirin affects the secretion of TNF protein | PMID:9281604 | Tnf | decreases expression | EXP | | 6480464 | CTD | Aspirin results in decreased expression of TNF mRNA | PMID:21353610 | Tnf | increases expression | EXP | | 6480464 | CTD | Aspirin results in increased expression of TNF protein | PMID:16413386 PMID:35537566 | Tnf | multiple interactions | EXP | | 6480464 | CTD | [Aspirin co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Aspirin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Aspirin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; SOCS2 affects the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] | PMID:15489888 PMID:16415877 PMID:17328244 PMID:19164858 PMID:37179038 PMID:37364758 PMID:9281604 | Tnf | affects response to substance | ISO | TNF (Homo sapiens) | 6480464 | CTD | TNF gene SNP affects the susceptibility to Aspirin; TNF polymorphism affects the susceptibility to Aspirin | PMID:17516296 PMID:20485159 | Tnf | increases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Aspirin results in increased expression of TNF protein | PMID:15024038 PMID:30885738 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Aspirin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein]; Aspirin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [TNF results in increased secretion of CXCL8 protein]; Aspirin promotes the reaction [Salmonella Vaccines results in increased expression of TNF protein] | PMID:10328874 PMID:12045164 PMID:14742690 PMID:15036249 PMID:15136050 PMID:15379866 PMID:15489888 PMID:19493461 | Tnf | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | [Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Azoxymethane results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Aspirin promotes the reaction [Acetic Acid results in increased expression of TNF protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of TNF protein]; lipopolysaccharide, Helicobacter pylori inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein] | PMID:11376495 PMID:11826407 PMID:15024038 PMID:20043115 PMID:20223228 PMID:21893697 PMID:22039321 PMID:30885738 PMID:35574720 | | ||||||||||||||||||||||
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