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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:16347
Term: (R)-carnitine
Definition: The (R)-enantiomer of carnitine.
Chemical ID: MESH:D002331
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionISOTnf (Rattus norvegicus)6480464CTDCarnitine results in decreased expression of TNF proteinPMID:18629605
Tnfincreases expressionISOTnf (Rattus norvegicus)6480464CTDCarnitine deficiency results in increased expression of TNF mRNAPMID:18597074
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased expression of TNF mRNA]; Carnitine inhibits the reaction [carbendazim results in increased expression of TNF protein]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of TNF protein]PMID:18597074 PMID:18852009 PMID:26562095 PMID:33965443 PMID:37312617
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