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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11415
Species: Mus musculus
RGD Object: Gene
Symbol: Thra
Name: thyroid hormone receptor alpha
Acc ID: CHEBI:40021
Term: tiratricol
Definition: A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.
Chemical ID: MESH:C010642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thramultiple interactionsEXP 6480464CTDMED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein]PMID:16324150
Thramultiple interactionsISOTHRA (Homo sapiens)6480464CTD3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRA protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]PMID:31566444 PMID:33049310
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