GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Th | increases expression | EXP | | 6480464 | CTD | Reserpine results in increased expression of TH mRNA | PMID:8666980 | Th | affects activity | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Reserpine affects the activity of TH protein | PMID:1981253 | Th | decreases expression | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Reserpine results in decreased expression of TH mRNA | PMID:20504635 | Th | increases activity | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Reserpine results in increased activity of TH protein | PMID:1978789 PMID:2862954 PMID:2863328 PMID:2872048 PMID:2881815 PMID:8369965 | Th | increases expression | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Reserpine results in increased expression of TH mRNA; Reserpine results in increased expression of TH protein | PMID:11438978 PMID:1350653 PMID:1359376 PMID:1676830 PMID:1687822 PMID:1687976 PMID:1698642 PMID:1705056 PMID:1714554 PMID:1717808 PMID:1970845 PMID:1976760 PMID:1978789 PMID:1981253 PMID:2568627 PMID:2862954 PMID:2863328 PMID:2872048 PMID:2881815 PMID:2882513 PMID:2883324 PMID:2903502 PMID:7478180 PMID:7532593 PMID:7545485 PMID:7616203 PMID:7911764 PMID:8369965 PMID:9210518 PMID:9691425 | Th | increases stability | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Reserpine results in increased stability of TH mRNA | PMID:11161478 | Th | multiple interactions | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]; Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Reserpine promotes the reaction [CREM protein binds to TH promoter]; Reserpine results in increased expression of and results in increased activity of TH protein | PMID:11438978 PMID:1687822 PMID:1714554 PMID:1717808 PMID:1981253 | | ||||||||||||||||||||||
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