GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Th | multiple interactions | EXP | | 6480464 | CTD | [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] | PMID:25582704 | Th | decreases expression | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Morphine results in decreased expression of TH protein | PMID:26386147 | Th | increases expression | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Morphine results in increased expression of TH protein | PMID:15541421 | Th | increases phosphorylation | ISO | Th (Rattus norvegicus) | 6480464 | CTD | Morphine deficiency results in increased phosphorylation of TH protein | PMID:24398105 | Th | multiple interactions | ISO | Th (Rattus norvegicus) | 6480464 | CTD | [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; Agmatine inhibits the reaction [Morphine results in increased expression of TH protein]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter] | PMID:15541421 PMID:24398105 PMID:25308750 PMID:25643298 | | ||||||||||||||||||||||
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