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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11411
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfa
Name: transforming growth factor alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfaaffects expressionEXP 6480464CTDbisphenol A affects the expression of TGFA mRNAPMID:32353937
Tgfadecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TGFA mRNAPMID:26063408
Tgfaincreases secretionEXP 6480464CTDbisphenol A results in increased secretion of TGFA proteinPMID:28703301
Tgfamultiple interactionsEXP 6480464CTD[ADAM17 protein co-treated with ADAM10 protein] affects the reaction [bisphenol A results in increased secretion of TGFA protein]; GW280264X inhibits the reaction [bisphenol A results in increased secretion of TGFA protein]PMID:28703301
Tgfaaffects expressionISOTgfa (Rattus norvegicus)6480464CTDbisphenol A affects the expression of TGFA mRNAPMID:25181051
Tgfaaffects expressionISOTGFA (Homo sapiens)6480464CTDbisphenol A affects the expression of TGFA mRNAPMID:20170705
Tgfaincreases expressionISOTGFA (Homo sapiens)6480464CTDbisphenol A results in increased expression of TGFA mRNAPMID:19371625 PMID:23019147 PMID:31230753 PMID:34831106
Tgfamultiple interactionsISOTgfa (Rattus norvegicus)6480464CTD[bisphenol A co-treated with tributyltin] results in increased expression of TGFA mRNAPMID:31129395
Tgfamultiple interactionsISOTGFA (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased expression of TGFA mRNA]PMID:34831106
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