GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Spp1 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of SPP1 mRNA | PMID:17178593 | Spp1 | multiple interactions | EXP | | 6480464 | CTD | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of SPP1 mRNA; [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of SPP1 mRNA | PMID:37567420 | Spp1 | decreases expression | ISO | Spp1 (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased expression of SPP1 mRNA | PMID:32643284 | Spp1 | decreases expression | ISO | SPP1 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of SPP1 mRNA; Glucose results in decreased expression of SPP1 protein | PMID:38000455 | Spp1 | increases expression | ISO | Spp1 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of SPP1; Glucose results in increased expression of SPP1 mRNA | PMID:12505755 PMID:20453393 | Spp1 | increases secretion | ISO | Spp1 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased secretion of SPP1 protein | PMID:20453393 | Spp1 | multiple interactions | ISO | Spp1 (Rattus norvegicus) | 6480464 | CTD | 1-Methyl-3-isobutylxanthine inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; 8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; Dinitrochlorobenzene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dinitrochlorobenzene inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dipyridamole inhibits the reaction [Glucose results in increased expression of SPP1 mRNA]; Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; morroniside inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] | PMID:20453393 PMID:32643284 | Spp1 | multiple interactions | ISO | SPP1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 protein]]; Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Melatonin inhibits the reaction [Glucose results in decreased expression of SPP1 protein]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 protein] | PMID:38000455 | | ||||||||||||||||||||||
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