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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11339
Species: Mus musculus
RGD Object: Gene
Symbol: Spn
Name: sialophorin
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spndecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SPN mRNA; bisphenol A results in decreased expression of SPN proteinPMID:37372067
Spnmultiple interactionsEXP 6480464CTDHDAC2 protein affects the reaction [bisphenol A results in decreased expression of SPN mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SPN protein]PMID:37372067
Spndecreases expressionISOSpn (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of SPN mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Spnincreases expressionISOSpn (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of SPN proteinPMID:32172062 PMID:32428650
Spnincreases methylationISOSpn (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of SPN genePMID:28505145
Spnmultiple interactionsISOSpn (Rattus norvegicus)6480464CTD[bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]PMID:32172062 PMID:32428650
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