GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sp1 | affects methylation | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the methylation of SP1 promoter | PMID:26046465 | Sp1 | decreases activity | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of SP1 protein | PMID:11714746 | Sp1 | decreases expression | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of SP1 mRNA; Arsenic Trioxide results in decreased expression of SP1 protein | PMID:17617380 PMID:20435036 PMID:25395240 PMID:25436934 PMID:28768059 | Sp1 | multiple interactions | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]; Arsenic Trioxide inhibits the reaction [SP1 protein binds to MYC promoter]; Arsenic Trioxide inhibits the reaction [SP1 protein binds to TERT promoter]; Arsenic Trioxide inhibits the reaction [SP1 protein results in increased expression of TERT mRNA]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein]; Arsenic Trioxide results in increased oxidation of and results in decreased activity of SP1 protein; Catechin inhibits the reaction [Arsenic Trioxide results in decreased expression of SP1 protein]; MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of SP1 protein] | PMID:11714746 PMID:15761015 PMID:25395240 PMID:26892147 PMID:28768059 | | ||||||||||||||||||||||
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