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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11334
Species: Mus musculus
RGD Object: Gene
Symbol: Sp1
Name: trans-acting transcription factor 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of SP1 mRNAPMID:21151649
Sp1increases expressionISOSP1 (Homo sapiens)6480464CTD[Cisplatin results in increased expression of SP1 protein] which results in increased expression of SLC31A1 mRNA; Cisplatin results in increased expression of SP1 mRNA; Cisplatin results in increased expression of SP1 proteinPMID:22914438 PMID:24132751
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTDCopper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA]PMID:24132751
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