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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11334
Species: Mus musculus
RGD Object: Gene
Symbol: Sp1
Name: trans-acting transcription factor 1
Acc ID: CHEBI:23414
Term: copper(II) sulfate
Definition: A metal sulfate compound having copper(2+) as the metal ion.
Chemical ID: MESH:D019327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1decreases activityISOSP1 (Homo sapiens)6480464CTDCopper Sulfate results in decreased activity of SP1 proteinPMID:22172574 PMID:26241054
Sp1decreases expressionISOSP1 (Homo sapiens)6480464CTD[Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of SLC31A1 mRNA; Copper Sulfate results in decreased expression of SP1 mRNAPMID:22172574 PMID:22914438
Sp1increases expressionISOSP1 (Homo sapiens)6480464CTDCopper Sulfate results in increased expression of SP1 mRNAPMID:19549813
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTDCopper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA]; Copper Sulfate inhibits the reaction [SP1 protein binds to SLC31A1 promoter]; Copper Sulfate inhibits the reaction [SP1 protein binds to SP1 promoter]; Zinc Sulfate inhibits the reaction [Copper Sulfate results in decreased activity of SP1 protein]PMID:22172574 PMID:24132751 PMID:26241054
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